What is the predicted frequency of LMLN given the MN blood type example: p=0.5395 and q = 0.4605?
What is the frequency of LMLM given the MN blood type example: p=0.5395 and q = 0.4605?
The predicted frequency of LMLN given the MN blood type example is 2pq. According to the given example, p = 0.5395 and q = 0.4605. The frequency of LMLN given the MN blood type example is calculated as follows: Let's denote L as the dominant allele that encodes for the presence of L antigen on RBCs, while l is the recessive allele that encodes for the absence of L antigen on RBCs. The M and N antigens are under the control of a single gene (LM). p = the frequency of L allele = frequency of LM + LL = frequency of LM + frequency of LL q = the frequency of l allele = frequency of ln + frequency of nn Since LM and LN are codominant, the frequencies of LM and LN can be added to get the frequency of LMLN. Given, p = 0.5395 and q = 0.4605. The genotype frequencies can be calculated using the Hardy-Weinberg equation as: p^2 + 2pq + q^2 = 1 where p^2 = frequency of LL, q^2 = frequency of nn, and 2pq = frequency of LMLN Let's first calculate the genotype frequencies for LM and LN alleles: p + q = 1 0.5395 + 0.4605 = 1 Therefore, the frequency of LM allele = p = 0.5395, and the frequency of LN allele = q = 0.4605. Now, we can use the genotype frequencies to calculate the frequency of LMLM and LMLN: Frequency of LMLM = p^2 = (0.5395)^2 = 0.2912 Frequency of LMLN = 2pq = 2(0.5395)(0.4605) = 0.497 Therefore, the predicted frequency of LMLM given the MN blood type example is 0.2912, and the predicted frequency of LMLN given the MN blood type example is 0.497.