Translation Initiation in Protein Synthesis

What happens when the ribosome scans the mRNA during translation initiation?

Will the next three bases automatically be lined up under the second RNA binding site on the ribosome?

Answer:

During translation initiation, the ribosome scans the mRNA to find the start codon. Once found, the next three bases are positioned under the second RNA binding site on the ribosome.

During translation initiation, the ribosome scans the mRNA in the 5' to 3' direction until it locates the start codon, which is typically AUG. At this point, the ribosome positions the next three bases under the second RNA binding site on the ribosome.

This process is essential for ensuring that the ribosome starts translation at the correct point on the mRNA and begins synthesizing the corresponding polypeptide chain.

For instance, if the start codon is AUG, the following three bases would be UUU, according to the genetic code. These bases will then form base pairs with the anticodons of tRNA molecules, facilitating the formation of peptide bonds and the elongation of the polypeptide chain.

Overall, the accurate positioning of the next three bases under the ribosome's second RNA binding site plays a crucial role in the initiation phase of protein synthesis.