Cell Division Checkpoints

What is the checkpoint where the cell checks the environment to determine if the conditions are right to proceed with cell division?

A) G checkpoint

B) Spindle checkpoint

C) M checkpoint

D) G2 checkpoint

Answer:

The correct answer is C) M checkpoint.

The M checkpoint, also known as the spindle checkpoint, is a crucial point in the cell cycle where the cell evaluates the environment to ensure that all conditions are suitable for cell division to proceed. This checkpoint occurs near the end of the metaphase stage of karyokinesis, a phase in mitosis.

At the M checkpoint, the cell specifically checks that all the sister chromatids are correctly attached to the spindle microtubules before moving on to anaphase. This meticulous process ensures the accurate distribution of genetic material to the daughter cells during cell division. Failure to pass this checkpoint can result in serious issues such as chromosome mis-segregation and aneuploidy.

Understanding the significance of the M checkpoint in regulating cell division is essential in comprehending how cells maintain genomic stability and integrity. By accurately assessing the cellular environment before proceeding with division, cells can safeguard against potential errors that could have detrimental consequences.